Intracranial fibroblastic neoplasms in the hamster from bovine papilloma virus.

Intracranial Fibroblastic neoplasms developed in 16 of 19 hamsters inoculated intracerebrally with bovine papilloma virus. The tumors presumably arose in the meninges and infiltrated the adjacent brain along the vascular channels. Tumor nodules that developed in the subcutis of the extremities, ears, and body were probably due to viremia following intracerebral inoculation. Fibroblasts of the cranial cavity and subcutis appeared to be more susceptible to the oncogenic action of bovine papilloma virus than fibroblasts elsewhere in the hamster.